Alexan is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Alexan is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

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There is also a highly conserved glutamate (Glu(28)) positioned on the opposite side of the active site to the canopy. In summary, regulation of CXCL16, ADAM10 and oxLDL expression may be an early event in the onset of DN and therefore all three proteins may represent potential new targets for diagnosis and therapeutic intervention in DN. Clinico-pathological study of diffuse interstitial pulmonary fibrosis of unknown etiology with special reference to its relationship to diffuse interstitial pneumonia Our study combines experimental and theoretical methods providing evidence for this effect, which has not been described previously, as well as a rationalization for it, based on atomistic grounds.

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The effects of axonally applied capsaicin on the discharge activity and compound action potential of the cat vagus, saphenous and phrenic nerves and the cervical sympathetic trunk were studied under in vivo and in vitro conditions. They might provide a useful and safe method to care for skin colonized by SA, without using antibiotics.

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The aim of this study was to assess physical and chemical properties of different body fluids in an ex vivo setting. The differential binding most likely governs the fate and function of the intracellular FasL fragments. We also emphasize the significance of CL-related metabolic pathways as new targets for drug discovery. The optimum concentration ranges, molar absorptivities, Ringbom ranges and Sandell sensitivities were also evaluated. Role of the kidney in hypertension due to renal infarction in the rat, determined by renal transplantation.

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Do Rh-negative women with first trimester spontaneous abortions need Rh immune globulin? The numbers of LC in the epidermis and DC in the lymph nodes draining irradiated skin sites were counted 24 h after the final irradiation. There was neither a difference between young and old nor between male or female volunteers. An automatic system for marine meiobenthos separation was developed by using laser-induced fluorescence technology. Disappearance of the medial epithelial seam (MES) is required to allow merging of the mesenchyme from both palatal shelves.

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Controlled clinical experimentation on delayed-action methaqualone Serological studies with X protein, tobacco mosaic virus, polymerized X protein, and virus reconstituted from nucleic acid and X protein.

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The blood ethanol concentrations, determined repeatedly within 4 hours by head space GC, were increasingly elevated after CMD or CPZ up to twice the respective control values. The demonstration of CSF oligoclonal bands in the reported patient implies that inflammation might be involved in the pathogenesis of superficial siderosis. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia.

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Expression of Middle-Component RNA of Cowpea Mosaic Virus: In Vitro Generation of a Precursor to Both Capsid Proteins by a Bottom-Component RNA-Encoded Protease from Infected Cells. In addition, it was assumed that the amino acids included in the miso have a significant influence on the remarkable disappearance of the three decreasing odorants. Using a rational drug design, novel compounds have been developed that selectively activate the human PPAR receptors, leading to lessening of hyperglycemia and hyperinsulinemia as well as reduction of lipid levels in conjunction with an increase of the beneficial HDL-cholesterol. To find the optimum Tw value, gated irradiation efficiency was evaluated for each configurable Tw value.

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The patients who survived the longest had minimal or no surgery. A novel mercuric reductase from the unique deep brine environment of Atlantis II in the Red Sea. The fused cells were subcloned and screened for cell type-specific markers. We analyzed the clinical features, tumor markers, serum/cerebrospinal fluid (CSF) antibodies of seven cases with anti-NMDA receptor encephalitis. In addition, our finding that performance was largely unimpaired following extensive lesions of lateral extrastriate area supports previous reports indicating that medial and lateral extrastriate visual areas differ in function.

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We found that arm posture had a significant effect on endpoint tracking accuracy and that subjects selected postures that improved tracking performance. The role of high hydrostatic pressure in the physiology of marine animals. The effects of FAC on apoptosis and cell cycle regulatory genes and proteins in SMMC-7721 cells were examined using an S series apoptosis and cell cycle gene array and Western blot analysis.

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Hence, nutrient and gas exchange is disabled and tissue cells became hypoxic regardless of the tissue blood flow. C4 neurons receiving short latency excitation from the C2 dorsal root ganglion due to intraspinal pathways have a distribution of directional sensitivities to pitch stimuli that is similar to that of the whole population. Patient American Society of Anesthesiologists classification was a significant predictor of wound dehiscence and overall donor-site complications. The impact of individual and community behavioral changes in response to an outbreak of a disease with high mortality is often not appreciated.

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To investigate the impacts of heavy metals from coal-fired power plant on the safety of the surrounding vegetables. We measured the rate of laboratory test completion and the cost-effectiveness of each intervention. In vitro, mesenchymal stem cells differentiate to osteoblasts when exposed to bone-inducing medium. The preoperative, intraoperative and early postoperative biochemical markers have predictive value of POPF. At least three isozymes have been cloned so far, which are called membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES.

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Children were subdivided into the following age groups: 1-2, 3-5, 6-11 and 12-18 years. Electron microscopic stains as probes of the surface charge of mitochondrial outer membrane channels. The web interface allows for constraining parts of the sequence to a known inside/outside location, and detailed results are displayed both graphically and in text format.

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This indicates the presence of a uni-directional interkingdom signaling system occurring from plants to bacteria. We obtained strains with the xylanase regulator gene, xlnR, overexpressed (HXlnR) and disrupted (DXlnR) derived from Talaromyces cellulolyticus strain C-1, which is a cellulase hyperproducing mutant. The pollution levels studied are moderate for some pollutants, although for others, especially NO2 and particles, these levels could entail a problem with regard to complying with the regulations in force.

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Additionally, breast cancer cells became more sensitive to cytotoxic and/or cytostatic effects of PCX delivered by FCD-1 and FCD-2. Monocyte and macrophage dysfunction plays a critical role in a wide range of inflammatory disease processes, including obesity, impaired wound healing diabetic complications, and atherosclerosis. We have explored the feasibility and safety of direct implantation of balloon expandable Edwards SAPIEN XT valve without prior balloon dilatation. Haloacetate analogs of pheromones: Effects on catabolism and electrophysiology inPlutella xylostella.

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After 8 weeks, the animals were sacrificed, and ground sections were obtained for histomorphometric analysis. High concentrations of progesterone and mifepristone mutually reinforce cell cycle retardation and induction of apoptosis. Trends in HIV-related morbidity among patients admitted to a South Indian tertiary hospital between 1997 and 2003. The positive conditioned stimulus produced an increase in response rate over the pre-conditioned stimulus period.

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The process of sorption is being increasingly used for ecofriendly and economic remediation of textile dye effluents. Trypanosoma musculi: influence of uric acid on in vitro formation of metacyclic trypomastigotes. A water soluble Hantzsch ester derivative of coumarin, DHPS, was synthesized and successfully applied in the fluorescent sensing nitric oxide (NO) in aqueous solution.

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The influence of fungicide concentration and treatment temperature on residue levels of pyrimethanil (PYR) in comparison with the commonly used fungicide imazalil (IMZ) was investigated in orange fruits following postharvest dip treatments. The results indicate that employment was affected only during the acute phase of a disorder and that early onset had lasting effects in terms of job level and salary. The usefulness of MRI in demonstrating important clinico-anatomic correlations in neuro-ophthalmologic disease of the brainstem is illustrated by a case of a pontine infarction causing abnormal horizontal gaze with preserved vertical gaze and convergence. The study group comprised 41 patients (26 males, 15 females, aged between 18-63 years, mean age 45 years), 23 with renal and 18 with ureteral stones, who underwent ESWL between March 2010 and January 2011. every 2 weeks for 16 weeks (8 doses) followed by 16 weeks with Bex 300 mg/m(2) orally.

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Purified bacterial phospholipases of the C type, which hydrolyse either phosphatidylinositol or phosphatidylcholine, increased the acetylcholine contracture responses of the muscles. A novel role for receptor like protein tyrosine phosphatase zeta in modulation of sensorimotor responses to noxious stimuli: evidences from knockout mice studies. When pregnant rats were X-irradiated at a dose of 100 R on gestational day 9.5, a considerable number of postnatally-viable hydrocephalic offspring resulted, all of which were accompanied with bilateral micro- or anophthalmia.

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The possibility of immunodeficiency should be kept in mind when evaluating patients with arthritis. In addition, a binary logistic regression technique was applied to identify causal factors affecting truck crash severity under normal and adverse weather conditions. After a median follow-up of 30 months all patients were free of complaints regarding the new stoma site. All patients were treated in the same way and were followed for one year.

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Fluid overload in HD patients was found to be lower in patients with high body mass index, indicating that dry weight was inadequately prescribed and/or difficult to achieve in overweight patients. Hematopoiesis is dependent upon the bone marrow microenvironment, which is comprised of multiple mesenchymal cell types, including fibroblasts, endothelial cells, osteoblasts, and stroma progenitors. Eight family caregivers of patients with advanced pancreatic cancer from oncology practices of a university-affiliated medical center were surveyed.

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Stereotaxic apparatus and operations in Russia in the 19th century. SBRT reirradiation is an effective and safe method to address positive or close margins after neoadjuvant chemoradiation and surgery for rectal cancer.

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Mechanism of antibody synthesis: size differences between mouse kappa chains. Immunocytochemistry confirmed results, but also pinpointed the location of phosphorylated signaling molecules. Squamous cell carcinoma of the head and neck treated with radiation therapy: the role of neck dissection for clinically positive neck nodes. Family history of breast cancer predicts breastmilk protein expression.

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Methadone-nicotine interactions in methadone maintenance treatment patients. The principles of pulmonary physiology as applied to clinical medicine. Changing axis deviation has been reported also during atrial fibrillation or atrial flutter. Due to social and economic consequences, a number of experimental and epidemiological studies have analyzed its etiology so far, in order to develop effective preventive and treatment measures.

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It was shown that in lateral flexion and in rotation, in 1 / 5 of patients the disorder affected only muscles which work on atlanto-occipital joints (latero- or torticaput), and in a further 1 / 5 it affected only muscles which work on the cervical spine (latero- or torticollis). We aim to evaluate expanding the potential donor pool for liver transplant in Singapore with the inclusion of marginal donors. The peri-ictal autonomic disturbances have been studied as predictors of seizure outcome and as markers of seizure onset. To examine a large osteological collection to assess the relations between the well-described means of quantifying cam deformities of the proximal femur-alpha angle (AA) and anterior femoral neck offset (AFNO)-and osteoarthritis of the lumbar spine.

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Simple method of detecting spore septum formation and synchrony of sporulation. Hypo-/aplasia of the nasal bones--an autosomal dominant inherited anomaly Participants were assessed with structured interviews and scales: SCID-I, Y-BOCS, Dimensional Y-BOCS, BABS, Beck Depression and Anxiety Inventories. The results had 9 CEF with positive fitness values with 15 distinct herbs.

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Ultrastructural and immunohistochemical characterization of normal mast cells at multiple body sites. Fibrous bone dysplasia of the proximal phalanx of the middle finger. Novel Ser79Leu and Ser81Ile substitutions in the quinolone resistance-determining regions of ParC topoisomerase IV and GyrA DNA gyrase subunits from recent fluoroquinolone-resistant Streptococcus pneumoniae clinical isolates. How well do waist circumference and body mass index reflect body composition in pre-pubertal children? The integration of new genetic and medical knowledge in clinical workflows requires the development of new paradigms for information management in which the ability to access and relate disparate data sources is essential.

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Acid eluates from glomeruli and from normal-appearing skin of three patients with systemic lupus erythematosus contained an antinuclear antibody. Focal overlying cortical or leptomeningeal enhancement on contrast-enhanced T1-weighted imaging or contrast-enhanced FLAIR imaging was observed in all patients. TNFR-1, TNFR-2 and FasR expression correlated positively with the percentage of lymphocytes, and negatively with the percentage of AM in HP. Serum Concentrations of Selected Heavy Metals in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland.

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Neuronal activation was investigated at the end of the period for maximum c-Fos expression. New potent modifiers of liver microsomal drug metabolism: 1-arylimidazoles.

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The self-reported height and weight were generally reliable in the middle-aged employed Japanese men and women. Results of palliative treatment of children with transposition of great vessels There is currently a weak evidence base for reducing the absorbed dose from CT to the threshold necessary to provide clinically relevant findings and research is needed urgently in this area. We then instituted a protocol with irinotecan (CPT-11) and vincristine.

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Furthermore, inhibition of G12 signaling by expression of the RGS domain of the p115-Rho-specific guanine nucleotide exchange factor (p115-RGS) in the PC3 and DU145 cell lines did not reduce cancer cell growth. Pollination mode and life form strongly affect the relation between mating system and pollen to ovule ratios.

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Humanoid robots have the potential to convey emotions to patients with schizophrenia, but their appearance seems of major importance for human-robot interactions. Peripheral maps and synapse elimination in the cerebellum of the rat. After a - 72 h culture, cell proliferation, carnitine palmitoyl transferase-1 mRNA level and the effect of etomoxir were also elucidated. To our knowledge, this is the first report of an antiaggressive benefit of this combination in forensic psychiatric patients. Ecology and epidemiology of anthrax in cattle and humans in Zambia.

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However, future research on intracellular mechanisms might become decisive for a better understanding of the similarities between the disorders. The cells growth behaviors including adhesion, proliferation, and cytoskeletal development was investigated by using cell viability assay and confocal observation. Respiratory function of intercostal muscles in supine dog: an electromyographic study. Constriction of the afferent artery in the BRVO region accelerated the restoration of potassium channels and Il6.

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Confined space-controlled hydroperoxidation of trisubstituted alkenes adsorbed on pentasil zeolites. Bone-grafts in the treatment of delayed union of tibial shaft fractures. The expected changes in CSF total (T)-tau, phosphorylated (P)-tau and Abeta42 levels were found in AD, confirming the diagnostic value of these biomarkers.

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Chromatin immunoprecipitation (ChIP) assays further establish that the proximal MDR1 promoter responds to cisplatin in a BMI1 dependent manner. This work has implications for the predictive value of FIB measurements, and points to the importance of the sediment reservoir.

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Conditional acceleration and external disinhibition of operant lever pressing by prereward, neutral, and reinforcing stimuli. We found optimal preservation and morphology of the chondrocyte cytoskeleton after simultaneous fixation and permeabilization with glutaraldehyde and Triton X-100. Perhaps strict Calvinists have less chance of being diagnosed and treated at an early stage because they conceal their depression and struggle on for a longer time. The results suggest that the pathway of drug development is more strongly associated with dose difference than are drug characteristics. Effects of infusion of molar solutions of hypertonic sodium lactate and sodium chloride on renal excretion of sodium and water.

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CT scan is the investigation of choice to confirm the diagnosis. All the operations were performed by a single surgeon (first author). The results of this study have demonstrated that the clinical Raman system can provide an accurate and objective method to diagnose prostate and bladder cancer in vitro. Cultural-educational work in military hospitals during World War II When given orally to passively sensitized rats at doses of 0.1 to 1.0 mg/kg, it inhibited migration of neutrophils to the pleural cavity in response to an antigen (ovalbumin) challenge.