The stretch-induced p42 and p44 MAPK activation was inhibited by the angiotensin receptor antagonist Aratan and by the angiotensin-converting enzyme inhibitor, captopril. Aratan administered at the onset of prehypertension is more effective than amlodipine in ameliorating hypertension and improving vascular remodeling and function, which is likely mediated by the renin-angiotensin-aldosterone system.
Other names for this medication:
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