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Disulfiram
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Disulfiram

Disulfiram is a drug that has been used as a deterrent agent in the treatment of alcohol use disorders. This section ventures into the journey of the discovery of the molecule, starting from the accidental discovery of its potential pathophysiological effects, thereafter becoming obscure due to lack of indications (alcohol use was not considered a problem!); and finally making a comeback and standing the rigorous test of time due to the determination of a few researchers, which makes it a story worth revisiting.

Other names for this medication:
Disulfiram, Antabuse, Anticol, Aversan, Esperal, Etabus, Tenutex,

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Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. These effects begin about 10 minutes after alcohol enters the body and last for 1 hour or more. Disulfiram is not a cure for alcoholism, but discourages drinking.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

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ARM provides a highly efficient and robust framework for discovering the most predictive set of phenotype definition criteria and rules from large datasets, and compared to other machine learning techniques, such as logistic regression and support vector machines, our preliminary results indicate not only significantly improved performance, but also generation of rule patterns that are amenable to human interpretation . Statistical evaluation with a paired t-test was performed concerning overall results and specific items modifications. Response to Nivolumab in a Patient With Metastatic Clear Cell Renal Cell Carcinoma and End-stage Renal Disease on Dialysis. Reduced migration capacity in vitro of peritoneal exudate cells from adult thymectomized, irradiated and bone marrow-protected rats. Some signs and symptoms appeared to be statistically significantly more prevalent in CRPS of the ankle/foot than in CRPS confined to the knee.

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The first case made a remarkable initial improvement which was sustained for two months, but then deteriorated and died. As far as dynamics is concerned, when observed over length scales exceeding the dimensions of the nanostructured features, the macroscopic diffusion is anisotropic.

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Improvements in diagnostic tools for early detection of psoriatic arthritis. Enzyme pretreatment of grass lignocellulose for potential high-value co-products and an improved fermentable substrate. Angiogram reveals a small angioma shunting the blood flow from the left middle cerebral artery into the lateral sinus.

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Intravitreal TA injections (approximately 20 mg) harbor a low risk of infectious or sterile endophthalmitis and pseudoendophthalmitis, if the injection and vehicle removal are performed under sterile conditions. The effects of different species of bile salts: deoxycholate, taurochenodeoxycholate, ursodeoxycholate, glycodeoxycholate, tauroursodeoxycholate, chenodeoxycholate and cholate (DCA, TCDC, UDCA, GDCA, TUDC, CDCA, CA) on bile secretion were examined in anesthetized rabbits using two different infusion routes. Characteristics of electrical skin resistance at acupuncture points in healthy humans. Normal control and male TO-2 cardiomyopathic hamsters were used. Effect of dibutyryl-cyclic AMP and dexamethasone on noradrenaline synthesis in isolated superior cervical ganglia.

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An experimental study of the immunogenic properties of guanine dependent mutants of murine typhus salmonellae The effect of NHT was tested for independence in a multivariate analysis. The proposed model is supposed to reproduce the dynamics of viral self-assembly for enveloped virus. A giant uterine leiomyoma simulating an ovarian mass in a 16-year-old girl: a case report and review of the literature.

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Various compromises may be effective for increasing genetic gain. Considering that the venular leaflets are made just by endothelial cells, a primary pathogenetic role has to be achieved to the endotheliopathy in the genesis of venous insufficiency. Introduction: the role of myoepithelial cells in integration of form and function in the mammary gland.

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