Burn size did not alter Ibuprofen half-life or area under the time-concentration curve. For the in vivo evaluation of Ibuprofen, rabbits as the main subjects, were infected with dermatophytes and treated with prepared Ibuprofen cream (15 mg/gm). An acute anaphylactic reaction after a conventional antipyretic dose of Ibuprofen was diagnosed in a child with allergic rhinitis, recurrent idiopathic urticaria, and nonimmunologic cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs and acetaminophen.
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